Hormone therapy and blood testing

What hormone replacement therapy can I access?

Oestradiol – “feminising” hormone

Finasteride (optional) – used to suppress testosterone, typically taken as a tablet

GnRH agonist (if required) – used to suppress testosterone, typically given as an injection

Testosterone – ‘masculinising’ hormone

Medroxyprogesterone acetate (optional) – this can be used to suppress menstruation whilst waiting for testosterone treatment to achieve the same effect.

GnRH agonist (if required) – this can be used to suppress menstruation if testosterone treatment alone does not successfully achieve it.

Why should I get tested?

Regular blood testing is important for two main reasons:

  • To make sure you’re on the right doses. Knowing how your hormone levels compare to “reference ranges” — what doctors think of as a “normal” level of oestrogen or testosterone for a healthy man or woman — will make sure you’re receiving the right dose.If your hormone levels are lower than they ought to be, that could mean you’re not getting the changes you want from HRT. Likewise, if your hormone levels are higher than they should be, that could mean you’re on too high a dose, and could be at risk of bad side-effects.
  • To spot any potential problems before they occur. Hormone replacement therapies come with a number of risks and side-effects, including things like:
    • Blood clots
    • Liver and kidney problems
    • Polycythaemia and erythrocytosis
    • Prolactinoma
    • Heart disease
    • High blood pressure

However, regular testing can reduce the risk of many of these things by flagging up any potential issues well before they become a serious problem. The exact risks will depend on what you’re taking, your physiology, and your family history, among other factors. For more information about the risks of hormone therapy, you should talk to your GP or an endocrinologist.

What blood tests do I need?

Baseline blood tests

  • Full blood count
  • Liver Function Test
  • HbA1c
  • Fasting lipids
  • Prolactin
  • Luteinising hormone
  • Follicle stimulating hormone
  • Testosterone
  • Oestradiol
  • Sex hormone binding globulin
  • Vitamin D
  • Prostate specific antigen (if over 40 years old)
  • Renal function (if indicated)

Regular monitoring

  • Liver function test
  • HbA1c
  • Fasting lipids
  • Prolactin
  • Oestradiol
  • Testosterone

The exact tests you need may vary, follow the guidance of your gender specialist if you have one. Many gender clinics have published guidance for GPs about the particular tests needed for people taking hormones, which you can find on the Gender Archive website.

Estradiol target range

350-750 pmol/L

Baseline blood tests

  • Full blood count
  • Liver Function Test
  • HbA1c
  • Fasting lipids
  • Prolactin
  • Luteinising hormone
  • Follicle stimulating hormone
  • Testosterone
  • Oestradiol
  • Sex hormone binding globulin
  • Vitamin D
  • Renal function (if indicated)

Regular monitoring

  • Full blood count
  • Liver function test
  • Fasting lipids
  • Testosterone
  • HbA1c (Nebido)

The exact tests you need may vary, follow the guidance of your gender specialist if you have one. Many gender clinics have published guidance for GPs about the particular tests needed for people taking hormones, which you can find on the Gender Archive website.

Testosterone target ranges

  • Testosterone gel – 15-20 nmol/L
  • Sustanon – trough level 8–12 nmol/L (day of injection, before it is given), peak level 25–30 nmol/L (one week after injection)
  • Nebido – trough level 15–20 nmol/L (day before injection)

Do I need any other tests?

In addition to blood tests, you may also need regular monitoring of things like blood pressure and weight. People taking blockers but not oestrogen or testosterone may need to have bone density monitored.

For more information on what tests are appropriate for you, talk to your GP, your gender specialist, or an endocrinologist.

Where can I get tested?

One way to get a blood test is to ask your GP for one. This will make sure your blood tests are a part of your medical records. You can also ask your GP for a hospital blood test form: this is a form you can take to a hospital phlebotomy department at your convenience, rather than having to keep a particular appointment.

Your GP should be able to offer blood tests even if you’re self-medicating.

Some sexual health clinics may be able to offer blood tests. These clinics will often provide a “drop-in” service where you don’t have to make an appointment, and will be able to keep your records separate from your main NHS record if that’s what you want.

The following clinics offer blood testing for trans people:

Some clinics might provide these tests without necessarily advertising them. To find out exactly what your local clinic can and can’t offer, you can phone up and ask.

Some clinics offer blood tests on a private basis (i.e. you pay for the test yourself) where you attend one of their clinics to have blood taken and tested (for example, clinics operated by Randox Health).

Finally, there are several private companies (for example, MediChecks) which will send you fingerprick tests for you to use at home. These come with a vial that you’ll fill with blood and send off to a lab. This can be a useful option if you can’t get a test through your GP or local clinic, but keep in mind that:

  • You might find it difficult to draw your own blood at home
  • A fingerprick test may be less accurate than a normal venous blood draw test

Dealing with needle phobia

The prospect of getting blood tests done might be particularly difficult if you have a fear of needles. However, there are some practical ways you can deal with this.

  • Guys and St. Thomas’ NHS Foundation Trust have produced a short guide on how to deal with a fear of needles.
  • EMLA cream or a similar local anaesthetic may be useful if you’re worried about pain.
  • If you’re taking any other medication that needs blood monitoring, they should be able to combine the tests so you only need to get your blood taken once.

Where can I find more information?

For more detailed information on monitoring and risk factors, read NHS Wales’ guidance on hormone monitoring.

From time to time there are supply issues with HRT. Read some guidance for GPs around different options.

Errors or omissions

Is there something missing from this page? Have you spotted something that isn’t correct? E-mail info@transactual.org.uk to let us know.

A disclaimer: TransActual do not provide medical, health, or legal advice. The content of this page is intended for information purposes only. It is not a substitute for medical advice, diagnosis or treatment from a medical professional. It is not a substitute for advice from a legal professional. We strongly suggest you consult a healthcare professional or legal professional for specific advice about your situation. TransActual do not advocate or recommend the purchase of any specific product and we do not endorse or guarantee the credentials or appropriateness of any health care provider, any product or any provider of legal services.

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